WG3 Expert Webinar on In silico skin models by Professor Tao Chen

Webinar of 19th of May, 9h00 – 10h00 GMT

In-silico modelling of chemical transfer across the skin

Professor Tao Chen (University of Surrey, UK)

In this talk I will give an overview of mechanism-based, computer (in-silico) modelling methods for predicting the transfer of chemicals across the skin. As the skin is an important physical and biological barrier, this topic underpins topical and transdermal delivery, personal care and cosmetics, as well as extraction of biomarkers from the skin. I will focus on approaches that translate the fundamental chemical transfer problems into mathematical equations, the solution of which provide the prediction of the extent and kinetics of chemical transfer, as well as how it is affected by the active ingredient’s physical & chemical properties, skin biophysics, the product formulation, and external forces. I will conclude the talk with discussion of the challenges and future opportunities.